Updated September 28, 2026
Compare online programs offering semaglutide and tirzepatide by price, care and speed, and find the plan that fits your goals and your budget.
Best Overall · Our #1 Pick for 2026
Price for Life: From $129/Mo, Never Goes Up
Other Brands We Rated
Brand-Name Wegovy® Pill & Pen Options
Provider Visits & Dietitian Support Included
Why It's Our #1
TotalRx scored highest overall. It's the only program we rated that locks your price for life, and it matched or beat every other program on care and speed.
The price you start on is the price you keep. Renewals never go up.
One monthly price covers the clinician, the medication and shipping.
Same-day clinician review, with medication usually at your door in about 2 business days.
Unlimited clinician visits and 24/7 messaging for as long as you're on the program.
Price for Life
Many GLP-1 programs advertise a low first month, then raise the price at renewal or as your dose goes up. TotalRx works differently: whichever plan you choose, that monthly rate is locked for as long as you stay. There's no membership fee on top.
Longer plans lower the monthly rate, but even month to month, the price you start on never changes.
Lock In Your Price| Plan length | Semaglutide | Tirzepatide |
|---|---|---|
| 12 months | $129/mo | $174/mo |
| 6 months | $139/mo | $189/mo |
| 3 months | $149/mo | $199/mo |
| Month to month | $199/mo | $249/mo |
TotalRx monthly rates, locked for life. No membership fee.
Real Costs
The first month is only part of the story. Here's an estimate of 12 months of semaglutide treatment at each program's published starting price, including any required membership.
Estimates use each program's published starting price in September 2026, before promotions, and assume the price doesn't change. Hers: $149/mo medication plus a $39 first-month, then $149/mo, membership. Other programs don't publish comparable pricing. Always confirm current prices with the program.
Side by Side
Starting prices as published by each program. Always confirm current pricing on the program's site.
| Program | Starting Price | Membership Fee | Price Locked | Care Included | Score |
|---|---|---|---|---|---|
| TotalRxBest Overall | $129/mo semaglutide $174/mo tirzepatide | None | Yes, for life | Unlimited visits + 24/7 messaging | 9.8 |
| Hers | $149/mo pill | $39 first month, then $149/mo | No | 24/7 messaging | 9.3 |
| MEDVi | $279/mo month to month | None listed | No | Provider visits + dietitian | 9.1 |
| Eden | See site | See site | Not stated | Ongoing check-ins | 8.9 |
| SkinnyRx | See site | See site | Not stated | Online consultation | 8.7 |
Getting Started
With most online programs, you can go from sign-up to your first dose in under a week, without an in-person appointment.
Answer questions about your health, weight history and goals. It takes about 10 minutes.
A licensed clinician checks whether a GLP-1 is right for you and writes a prescription if it is.
Your medication arrives in temperature-controlled packaging, with instructions and ongoing support.
Our Method
Every program is scored out of 10 on the same four weighted factors. We review each sign-up flow, the published prices and the plan terms.
Real monthly cost to start and continue, fees, and what's included for the price.
Access to licensed clinicians, follow-ups, dose changes and messaging.
How fast you're reviewed and how quickly medication reaches you.
Sign-up, support quality, and how easy it is to change or cancel.
GLP-1 Guide
GLP-1 medications have become one of the most effective tools for weight loss. Here's how they work, who they're for, and how to get the most from them.
They copy a gut hormone that tells your brain you've eaten enough, so portions shrink naturally.
Food leaves the stomach more slowly, so you stay satisfied for longer between meals.
More stable blood sugar means fewer energy dips and fewer cravings.
Trial results are for the brand-name medications studied, alongside diet and activity changes.
A licensed clinician makes the final decision based on your health history.
FAQ
It scored highest on price and value, our most heavily weighted factor, and matched or beat the other programs on care and speed. It's also the only program we rated that locks your monthly price for life, with no membership fee.
Semaglutide is $129/mo on a 12-month plan, $139/mo on 6 months, $149/mo on 3 months, or $199/mo month to month. Tirzepatide is $174/mo, $189/mo, $199/mo, or $249/mo month to month. Whichever you choose, the rate is locked for as long as you stay.
Brand-name medications like Wegovy® and Zepbound® are FDA-approved. Compounded semaglutide and tirzepatide are made by licensed pharmacies but aren't FDA-approved and don't go through the same review for safety, effectiveness and quality. They usually cost much less.
No. The programs on this page are cash-pay, so there's no prior authorization or waiting on an insurer.
With the fastest programs, a clinician reviews your intake the same day and medication arrives within a few business days.
Results vary. In clinical trials of the brand-name medications, adults lost around 15% of body weight on semaglutide and around 20% on tirzepatide over roughly a year and a half, alongside diet and activity changes.
Often, yes. Many programs let you switch medications if your clinician agrees it's appropriate. Ask about any price difference before you switch.
Most month-to-month plans can be cancelled before the next billing date. Longer plans may have different terms, so check before you sign up.
We may earn a commission when you sign up with a program through links on this page. It keeps the site free to use. See our advertiser disclosure.
Advertiser Disclosure. WeightLossRated is an advertising-supported comparison site. We may receive compensation from the companies featured on this page, which may affect which companies appear and in what order. We do not list every company or offer available.
Medical Disclaimer. This page is for general information only and is not medical advice. Consult a licensed healthcare professional before starting any medication. Compounded GLP-1 medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality. Trial results refer to the brand-name medications studied. Individual results vary.
Trademarks. Wegovy® is a registered trademark of Novo Nordisk A/S. Zepbound® is a registered trademark of Eli Lilly and Company. All other names and logos belong to their respective owners and are used for identification only.
